Metformin Stella Dosage/Direction for Use

Administration: Metformin STELLA 850 mg is administered orally with or after meals.
Dosage: Adults: Monotherapy and combination with other oral anti-diabetic agents: The usual starting dose is one tablet 2 or 3 times daily. After 10 to 15 days the dose should be adjusted on the basis of blood glucose measurements. A slow increase of dose may improve gastrointestinal tolerability. The maximum recommended dose of metformin is 3 g daily, taken as 3 divided doses. If transfer from another oral anti-diabetic agent is intended: discontinue the other agent and initiate metformin hydrochloride at the dose indicated previously.
Combination with insulin: Metformin is given at the usual starting dose of one tablet 2 - 3 times daily, while insulin dosage is adjusted on the basis of blood glucose measurements.
Children and adolescents: Metformin STELLA 850 mg film-coated tablet can be used in children from 10 years of age and adolescents.
Monotherapy and combination with insulin: The usual starting dose is one tablet of 500 mg or 850 mg once daily. After 10 to 15 days the dose should be adjusted on the basis of blood glucose measurements. The maximum recommended dose of metformin is 2 g daily, taken as 2 or 3 divided doses.
Renal impairment: A GFR should be assessed before initiation of treatment with metformin containing products and at least annually thereafter. In patients at an increased risk of further progression of renal impairment and in the elderly, renal function should be assessed more frequently, e.g. every 3 - 6 months. (See table.)

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